Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
Identifieur interne : 002713 ( Main/Exploration ); précédent : 002712; suivant : 002714Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses
Auteurs : O. B. Kazakova [Russie] ; N. I. Medvedeva [Russie] ; I. P. Baikova [Russie] ; G. A. Tolstikov [Russie] ; T. V. Lopatina [Russie] ; M. S. Yunusov [Russie] ; L. Zaprutko [Pologne]Source :
- Russian Journal of Bioorganic Chemistry [ 1068-1620 ] ; 2010-11-01.
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Abstract
Abstract: The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.
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DOI: 10.1134/S1068162010060142
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The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11) was detected with the selectivity index SI 35.</div></front></TEI><affiliations><list><country><li>Pologne</li><li>Russie</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Kazakova, O B" sort="Kazakova, O B" uniqKey="Kazakova O" first="O. B." last="Kazakova">O. B. Kazakova</name></noRegion><name sortKey="Baikova, I P" sort="Baikova, I P" uniqKey="Baikova I" first="I. P." last="Baikova">I. P. Baikova</name><name sortKey="Kazakova, O B" sort="Kazakova, O B" uniqKey="Kazakova O" first="O. B." last="Kazakova">O. B. Kazakova</name><name sortKey="Lopatina, T V" sort="Lopatina, T V" uniqKey="Lopatina T" first="T. V." last="Lopatina">T. V. Lopatina</name><name sortKey="Medvedeva, N I" sort="Medvedeva, N I" uniqKey="Medvedeva N" first="N. I." last="Medvedeva">N. I. Medvedeva</name><name sortKey="Tolstikov, G A" sort="Tolstikov, G A" uniqKey="Tolstikov G" first="G. 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